Drug companies will do anything

Introduction Post

For about a year I've been having trouble getting the allergy meds I need. Ever since the people who make Benadryl decided it was a good idea to put calcium in the pills. Calcium tears up my stomach. I can't take anything that contains calcium.

It's well documented in Annals of Allergy that people with allergies tend to have acid stomach. It's well known among GI doctors that calcium stimulates stomach acid.
The makers of Benadryl are apparently unaware of this. Their response to my upset emails was basically "come hold our hands and teach us". They don't do research or even read the medical journal in their own field! Since manufacturers copy each other like sheep, store brand versions are the same.

I've been noticing this in other meds also, and even worse. Pseudoephedrine (sudafed) contains calcium now, as does almost every other pill I look at. The few pills that don't contain calcium contain lactose - a wonderful idea when many people are lactose intolerant!

But even worse, the Sudafed brand of phenylephrine (an alternative decongestant) contains vinyl.
That's right, one of the ingredients is known to cause allergies. It's listed as polyvinyl alcohol.

I found a Walgreen's combo that contains acetaminophen with phenylephrine, and another version that also contains chlorpheniramine, with no calcium or lactose. I've been using these since last fall.

This is the only way I've found to get an antihistamine without the garbage that upsets my stomach.

Today I went to the Edgewater Walgreen's to get more. Mold is in the red zone and ragweed moderately high and on top of that I have a cold. I need this medicine more than ever. They had one box of the one without chlorphen. The associate told me they hadn't received the one with chlorphen since July 13. They're either discontinuing or changing it. Great timing, at the height of allergy season!

She checked all the other options and they all have calcium or lactose. A few years ago my stomach decided not to digest corn anymore - The Walgreen's brand of chlorphen doesn't have the other stuff, but it does have corn starch, which seems to be another common ingredient of theirs, and is one of the common food allergens.

I think customers are catching on to the meds that are upsetting their stomachs with calcium, because Walgreen's wasn't out of those. Only the ones without calcium.

Very anxious and disappointed, I looked at the sleep aids. They are the same medicine as Benadryl - an antihistamine. They all contain calcium except one. Sominex contains both calcium and lactose.
There is one that doesn't have either - Unisom.

Yay? No! Unisom contains phthalates! It lists "polyvinyl acetate phthalate" as an ingredient.
They are deliberately putting an ingredient that *causes* allergies in their medicine!

I don't know why they can't just use cellulose and iron oxide to make the pills. Why do they think calcium, lactose, artificial sweeteners, phthalates and other garbage are necessary? Are they trying to make us sick?

I wouldn't put it past them.

Flu shot not dangerous for egg-allergic? Let's think for ourselves.

Introduction post

I saw a news article saying there is now an egg-free flu vaccine. Yay! Now I won't get sick from my non-IgE egg allergy when I get the flu shot required for my job.

Turns out it's not so easy. The distributor of the shot is taking orders but it hasn't shipped yet, and I didn't find a provider who will get it and give it to me. My primary offered to let me order a package of 5-10 vaccines, but it is too expensive.

When I talked to my allergist she said they don't have the egg-free vaccine because the regular vaccine is safe for people, including children, who have severe IgE egg allergy. I said that can't be safe and she said it's been well studied.

I looked it up and found this Medicine Net article that says thousands of egg-allergic children have been studied and tolerated the vaccine with no reaction.

http://www.medicinenet.com/script/main/art.asp?articlekey=174223

And here is the recently published study referred to in the Medicine Net article. 112 severely egg-allergic children were administered the vaccine and showed no allergic reaction.

http://www.annallergy.org/article/S1081-1206(12)00681-3/

This is a time for us patients and those with allergic children to think for ourselves. No matter how many studies there are, I will never believe there is no risk to a person with severe IgE egg allergy. It's common sense! The risk may be rare, as it says in the Medicine Net article. But there is a risk.

If I had severe IgE egg allergy, I would not get the flu shot. But if I did want one for myself or a child with severe egg allergy, I would insist on getting it from an allergist and having them observe us for at least 30 minutes in case of a reaction. If the allergist did not agree to that, I would find one who did.

I have non-IgE egg allergy and do in fact get symptoms from the flu shot. In 2011, I had symptoms for 3 days. In 2012, 1 and 1/2 days. This year is worse than last year. I got the regular shot two days ago and the symptoms haven't cleared up yet. Looks like it will be at least 3 days. I think weather may be a factor. It was damp and cloudy when I got the shot and I get symptoms in that weather anyway.

The allergy establishment does not address non-IgE allergies at all. They didn't acknowledge the existence of them until 2009. They don't teach medical students about non-IgE allergies. MDs, including allergists, are not trained to understand or treat them. Those who are interested in non-IgE allergies learn about it independently.

If I had waited for the allergy establishment to address my symptoms instead of figuring out my own non-IgE food allergies and learning about them from others in the medical field, I would have had a miserable life of illness. How long before they accept and begin using information and diagnostic tools that have been available for decades?

I wish they would at least mention non-IgE allergies in medical school so I could stop explaining the term "non-IgE allergy" to every MD and nurse I talk to. My allergist and my primary doctor are the only ones I can discuss this with.because they are smart, receptive, understand my history and respect what I've learned about my non-IgE allergies.

Thank you,

Julia Baresch

Chicago

Is yeast a culprit?

Introduction post 

Someone I know used to get 2- and 3-day headaches whenever a storm came in. In this climate that means at least 2 or 3 times a month through spring, summer and early fall. I also got symptoms from storms, but not as bad as hers. Last winter she read a book by someone who believes wheat is bad for people because it's been cross-bred and hybridized since the early 1900's, and she stopped eating wheat products.

A few weeks later, in February, a very low-pressure, very damp storm came in and I wasn't feeling well. I asked her if she had a headache and she said no, she felt fine. She said she had stopped all wheat products except breaded items like fried chicken. She hadn't had any bread. She was yeast-free.

I was so impressed I decided to try avoiding yeast and stopped eating yeast breads. I found that many crackers also contain yeast. I ate yeast-free crackers and corn pasta. After I few weeks I began eating wheat pasta again with no ill effect except it seems harder to digest than rice, my other starch. (I recently learned that wheat and white flour contain chains of fructose molecules, and sugars upset my stomach. So now I'm trying a wheat-free diet.)

I've noticed a big difference with my yeast-free diet! My sinus symptoms improved by about 70 - 80% and my sensitive stomach got a bit better. The nagging sinus pain I've had frequently all my life is almost gone - I've only had it a few times since February.

With summer and hot humid weather I noticed sinus pressure and pain from mold allergy, but not as bad as usual. So far it's 70 - 80% less than when I was eating yeast. And now that it's ragweed season that percentage is holding - I notice symptoms from the ragweed but much better than before.

Is it too much of a coincidence that both I and someone I happen to know would be allergic to yeast? Is there some other mechanism involved in this? Is it a common reaction? How could we tell when every American eats yeast bread every day from babyhood? Any reaction would seem normal and the symptoms attributed to other causes, like my mold allergy.

I'd like to find out. So far I've learned the same yeast, Saccharomyces cerevisiae, is used in both bread and beer.

Back in the day I used to get sinus pressure after drinking beer. I eventually stopped and since there are no ingredient labels on alcoholic beverages I couldn't determine the cause. Now it seems it may have been the yeast. I've known others who got symptoms from beer - they could try avoiding yeast and see what happens.

S. cerevisiae a unique organism with a structure unlike that of other yeasts or of any known organism.

Antibodies against S. cerevisiae are found in 60–70% of patients with Crohn's disease and 10–15% of patients with ulcerative colitis (and 8% of healthy controls).  https://en.wikipedia.org/wiki/Bread_yeast 

A specific antibody to S. cerevisiae is ASCA, a marker of intestinal inflammation. It is elevated in certain schizophrenic populations.

http://www.ncbi.nlm.nih.gov/pubmed/22446142 

I wonder if it's elevated in other populations, such as those of us with allergies?

A concentrated dose of S. cerevisiae modulates immune system response involving T-cells and Natural Killer cells (lymphocytes) http://www.ncbi.nlm.nih.gov/pubmed/21501093

http://www.ncbi.nlm.nih.gov/pubmed/21501093 http://www.ncbi.nlm.nih.gov/pubmed/16285232 A 6-year-old boy had allergic reactions only to fresh-baked bread and pizza (yeast in the pizza crust).

Commercial breadmakers add cysteine to bread to have it rise in ten to twenty minutes instead of three to four hours.

https://en.wikipedia.org/w/index.php?title=Talk:Saccharomyces_cerevisiae&action=edit&section=9 

Does the cysteine do something to change the way our immune systems respond to the yeast? I don't have time to make homemade bread and try it. It would be interesting to see if a person who gets symptoms from commercial yeast products gets symptoms from homemade bread made with unaccelerated yeast. 

I'm so happy with the big improvement in my symtoms! Wheat and yeast are relatively easy to avoid, unlike my other allergens. I'm hoping to learn more, and I hope this preliminary information is helpful.

Julia Baresch

Chicago

Non-IgE Egg Allergy and the Flu Shot

Introduction post

Note: This article is about Non-IgE allergy, a different type of allergy than the one that causes the dangerous reaction of anaphylactic shock. If you or your loved one has IgE allergy to egg - determined by a positive skin test reaction within 30 minutes - you have potentially dangerous reactions and should receive your flu shot only from an allergist with experience in this. Terminology of Allergies

I got a flu shot once in the 1990's, before I knew I'm allergic to egg. I was sick for three days with fatigue and congestion. After that I never got a flu shot again.

Now I have a great job in a hospital and a flu shot is mandatory. Last year I considered getting a medical exemption, but I'm as concerned about catching the flu as my employer is about having it spread. I don't work with patients, but I see patients and visitors in the hallways. My allergist wanted me to get flu shots ever since she did skin tests for egg allergy in 2006, which were negative.

I discussed this with my allergist and she told me the amount of egg in flu shots has been greatly reduced since the old days and that many patients with egg allergy tolerate it well. I decided to go ahead and get one.

I planned it so I'd have time to be sick - I got it at 4:00 on a Friday afternoon with no plans for the weekend. Since non-IgE allergies are not very well understood, I'm recording my symptoms here to help others with allergies and to use for research.

- 1/2 hour after the shot, I felt lightheaded for a minute or two. I was just wondering if I should leave work when it passed.
- 2 hours after the shot, I had sinus pressure with a little pain.
- That evening I had sinus pain and pressure, fatigue, and stomach pain. These symptoms continued into the next day (Saturday).
- Sunday (2nd day) the the sinus pain was gone and the fatigue was much better, but the sinus pressure was still noticeable.
- Monday (3rd day) the sinus pain and pressure were gone but I still had some fatigue and drainage.

This fatigue from egg allergy is worse than ordinary fatigue from being tired, it is very hard to do things and makes me want to sleep all the time. It's one of the symptoms I was noticing when I identified my egg allergy in 2001.

I've done a search of the internet and looked in my immunology text, but although there is lots of information about what one cell does to another, I haven't found any about global symptoms related to immune reaction types. I know my egg allergy is not Type I (IgE) because the test was negative. I know it's not Type IV (T-cell) because I have that with dust and cigarette smoke and the symptoms are different from my egg reaction.  Also a Type IV reaction has a 24-hour delay and my egg symptoms don't. So it's either Type II or Type III, both of which feature the activities of IgG and IgM mediators. I will keep looking for information about symptoms...

This year I'm getting my flu shot next weekend. Something to look forward to! :p :-)

Remember, this is a description of Non-IgE egg allergy. If you have IgE allergy with a positive skin test reaction in 30 minutes or less, a flu shot is potentially dangerous and you should only get one from an experienced allergist.

I hope this is helpful!
Julia Baresch
November 4, 2012

Soybean oil in hand lotion

Introduction post

Hi everyone,

I have some recent experiences with hand lotion and soybean oil to share.

As you know, I'm allergic to soy. By the symptoms it appears to be non-IgE allergy. About 2 months ago I was in an office and used a little lotion that was by the sink. It worked very well and I thought I might buy some for myself - but on checking the ingredients it contains soybean oil. I had sinus pain for the rest of the day, probably from the oil.

A few weeks later I was at another place and used a little of the fancy scented lotion in the bathroom. Then I remembered my earlier experience and checked the ingredients and it also contained soybean oil. This time I washed it off and didn't get any sinus pain.

I've been using the same types of natural soy- and camomile-free lotions for a few years, and I hadn't looked at other lotions. I don't remember soybean oil being such a common ingredient. But maybe it was and I thought it didn't matter since I wasn't eating it.

When I first learned I have IgE allergy to ragweed I learned that camomile cross-reacts with ragweed and stopped using cosmetics that contain it, with a noticeable improvement in symptoms. I've also gotten sleepy from antihistamine cream, just like taking an antihistamine orally. So now I know from experience that things put on my skin are absorbed into my system, including soybean oil.

So it's important to check the ingredients on lotions, deodorants, and such for allergens. Remember, if you have allergy symptoms from mid-August to the first frost, it's probably ragweed allergy, and avoiding camomile will probably help. :-) And remember, lecithin is a soy product.

Take care,
Julia

NIH Proposed Guidelines for Managment of Food Allergy

Introduction post

Hi anyone who is reading this, I hope the information here has been helpful. I recently learned the NIH has issued proposed guidelines for the managment of food allergies. I'm reading them and I plan to post some comments.

They have acknowledged non-IgE food allergies! Yay! And they use the term "non-IgE food allergy" instead of confusing terms like "non-allergic"! Hurray! The establishment is starting to accept and use knowledge about non-IgE food allergies, and now fewer people will suffer undiagnosed.

If you would like to read the proposed guidelines, here is the link
http://www3.niaid.nih.gov/topics/foodAllergy/clinical/Who/comments.htm

Anyone who likes may post comments, the deadline is May 6. In my day job I've learned a lot about the FDA, and this is standard procedure. They propose and request comments, they collect the comments and consider them, and when the final rule or guideline is issued the FDA writes a preamble in which they discuss the comments and why they did or did not adopt each suggestion. I hope the NIH writes a discussion also.

I'm so happy about this progress! Yay!

Julia :)
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